Table 4 Multivariable models showing the hazard ratios for the associations between enrolment creatinine clearance and times to overall mortality
| Hazard ratios (95% confidence intervals) | ||
|---|---|---|
| Enrolment characteristic | Model 1 | Model 2 a |
| Creatinine clearanceb (mL/min) | ||
| ≥60 (reference) | 1.0 | 1.0 |
| < 60 | 1.73 (1.19-2.51)c | 1.25 (0.84-1.86) |
| Age (per 10 year increase) | 1.22 (1.02-1.45)d | 1.27 (1.07-1.51)c |
| Male sex (compared with female sex) | 1.91 (1.29-2.81)e | 2.40 (1.61-3.59)f |
| WHO stage 2 (compared with stage 1) | 1.54 (1.09-2.18)c | 1.37 (0.97-1.95) |
|
CD4 cell count (per 50 cells/mm3 increase) | 0.96 (0.91-1.01) | 0.97 (0.91-1.02) |
| Haemoglobin (per 1 g/dL increase) | 0.76 (0.72-0.81)f | 0.78 (0.73-0.83)f |
| Initiation of antiretroviral therapy (compared with no initiation) | 1.36 (0.91-2.02) | 1.35 (0.90-2.01) |
| Weight (per 1 kg increase) | 0.95 (0.93-0.97)f | |