Reduced renal function is associated with progression to AIDS but not with overall mortality in HIV-infected kenyan adults not initially requiring combination antiretroviral therapy

Table 3 Multivariable models showing the hazard ratios for the associations between enrolment estimated glomerular filtration rate and times to meeting criteria for initiation of cART^a

	Hazard ratios (95% confidence intervals)
Enrolment characteristic	Model 1	Model 2 ^b
Glomerular filtration rate (mL/min/1.73 m²)^c
≥60 (reference)	1.0	1.0
< 60	1.39 (1.22-1.58)^d	1.41 (1.23-1.61)^d
Age (per 10 year increase)	1.03 (0.98-1.08)	1.03 (0.98-1.08)
Male sex (compared with female sex)	1.22 (1.08-1.36)^e	1.29 (1.14-1.45)^d
WHO stage 2 (compared with stage 1)	1.35 (1.23-1.49)^d	1.30 (1.18-1.44)^d
CD4 cell count (per 50 cells/mm³ increase)	0.88 (0.87-0.90)^d	0.89 (0.87-0.90)^d
Haemoglobin (per 1 g/dL increase)	0.90 (0.88-0.92)^d	0.91 (0.89-0.93)^d
Weight (per 1 kg increase)		0.98 (0.98-0.99)^d

^aCombination antiretroviral therapy, defined as development of either CD4 cell count < 200 cells/mm³ or WHO disease stage 3 or 4
^bModel 1 adjusted for weight
^cEstimated using the 4-variable Modification of Diet in Renal Disease Equation
^dP < 0.0001
^eP < 0.001